Contract Detail

1. MICHAEL WEIL PH.D. (CO-I) HAS INITIATED A STUDY IN WHICH MALE C3H MICE WERE EXPOSED TO A SINGLE DOSE OF 28SI AT BROOKHAVEN NATIONAL LABORATORY TRANSPORTED TO COLORADO STATE UNIVERSITY (CSU) AND ARE ADMINISTERED ASPIRIN IN THE DRINKING WATER. THE PRIMARY ENDPOINT OF THESE STUDIES IS TUMOR FORMATION. WE WILL USE THESE MICE TO ALSO THE EFFECTS OF ASPIRIN ON CARDIAC FUNCTION CARDIAC MITOCHONDRIAL FUNCTION AND CARDIAC TISSUE REMODELING. THERE WILL BE 4 EXPERIMENTAL GROUPS: SHAM-IRRADIATED CONTROLS WITH REGULAR DRINKING WATER SHAMIRRADIATED CONTROLS TREATED WITH ASPIRIN 28SI EXPOSED MICE WITH REGULAR DRINKING WATER 28SI EXPOSED MICE TREATED WITH ASPIRIN. FOR STATISTICAL POWER WE WILL ASSESS 10 MICE PER GROUP. 2. DR. WEIL WILL PERFORM A STUDY IN WHICH MALE C3H MICE ARE EXPOSED TO CHRONIC LOW-DOSE RATE NEUTRONS IN HIS NEUTRON FACILITY AT CSU FOR 400 DAYS AND ADMINISTERED ASPIRIN IN THE DRINKING WATER. THE PRIMARY ENDPOINT IS TUMOR FORMATION UP TO 400 DAYS AFTER THE COMPLETION OF NEUTRON EXPOSURE. WE WILL ASSESS CARDIAC FUNCTION CARDIAC MITOCHONDRIAL FUNCTION AND CARDIAC TISSUE REMODELING IN THESE MICE. THERE WILL BE 4 EXPERIMENTAL GROUPS: SHAM-IRRADIATED CONTROLS WITH REGULAR DRINKING WATER SHAM-IRRADIATED CONTROLS TREATED WITH ASPIRIN NEUTRON-EXPOSED MICE WITH REGULAR DRINKING WATER NEUTRON-EXPOSED MICE TREATED WITH ASPIRIN. WE WILL ASSESS 10 MICE PER GROUP.

1. MICHAEL WEIL PH.D. (CO-I) HAS INITIATED A STUDY IN WHICH MALE C3H MICE WERE EXPOSED TO A SINGLE DOSE OF 28SI AT BROOKHAVEN NATIONAL LABORATORY TRANSPORTED TO COLORADO STATE UNIVERSITY (CSU) AND ARE ADMINISTERED ASPIRIN IN THE DRINKING WATER. THE PRIMARY ENDPOINT OF THESE STUDIES IS TUMOR FORMATION. WE WILL USE THESE MICE TO ALSO THE EFFECTS OF ASPIRIN ON CARDIAC FUNCTION CARDIAC MITOCHONDRIAL FUNCTION AND CARDIAC TISSUE REMODELING. THERE WILL BE 4 EXPERIMENTAL GROUPS: SHAM-IRRADIATED CONTROLS WITH REGULAR DRINKING WATER SHAMIRRADIATED CONTROLS TREATED WITH ASPIRIN 28SI EXPOSED MICE WITH REGULAR DRINKING WATER 28SI EXPOSED MICE TREATED WITH ASPIRIN. FOR STATISTICAL POWER WE WILL ASSESS 10 MICE PER GROUP. 2. DR. WEIL WILL PERFORM A STUDY IN WHICH MALE C3H MICE ARE EXPOSED TO CHRONIC LOW-DOSE RATE NEUTRONS IN HIS NEUTRON FACILITY AT CSU FOR 400 DAYS AND ADMINISTERED ASPIRIN IN THE DRINKING WATER. THE PRIMARY ENDPOINT IS TUMOR FORMATION UP TO 400 DAYS AFTER THE COMPLETION OF NEUTRON EXPOSURE. WE WILL ASSESS CARDIAC FUNCTION CARDIAC MITOCHONDRIAL FUNCTION AND CARDIAC TISSUE REMODELING IN THESE MICE. THERE WILL BE 4 EXPERIMENTAL GROUPS: SHAM-IRRADIATED CONTROLS WITH REGULAR DRINKING WATER SHAM-IRRADIATED CONTROLS TREATED WITH ASPIRIN NEUTRON-EXPOSED MICE WITH REGULAR DRINKING WATER NEUTRON-EXPOSED MICE TREATED WITH ASPIRIN. WE WILL ASSESS 10 MICE PER GROUP.