Exact Contract Story

VAPING CESSATION AMONG YOUTH: EVALUATING THE FEASIBILITY AND EFFICACY OF A VIRTUAL IN-PERSON CBT AND AN APP-BASED CBT4CBT - PROJECT ABSTRACT E-CIGARETTES ARE THE MOST POPULAR NICOTINE-DELIVERY DEVICES USED BY US ADOLESCENTS. MANY ADOLESCENTS DO NOT LIKE BEING ADDICTED TO E-CIGARETTES AND WANT TO QUIT. HOWEVER, THERE ARE NO EMPIRICALLY VALIDATED INTERVENTIONS TO HELP THEM QUIT USING E-CIGARETTES. WE HAVE DEVELOPED AN ADOLESCENT-FOCUSED SMARTPHONE-APP CALLED KICK-NIC!© THAT USES AN ENGAGING, MULTI-MEDIA RICH, AND INTERACTIVE COGNITIVE-BEHAVIORAL THERAPY PLATFORM TO TEACH COPING SKILLS FOR E-CIGARETTE-SPECIFIC TRIGGERS AND SUPPORT CESSATION. APP CONTENT TO ADDRESS E-CIGARETTE APPEAL, QUIT MOTIVATIONS, AND COPING SKILLS, WAS DEVELOPED USING FOCUS GROUP EVIDENCE FROM 60 ADOLESCENT E-CIGARETTE USERS. THE STRUCTURE, FORMAT AND DESIGN OF THE APP WAS DEVELOPED USING ITERATIVE FEEDBACK FROM 14 ADOLESCENTS. A FEASIBILITY PILOT WITH 19 ADOLESCENTS WHO USED THE APP, INDICATED THAT IT WAS ENGAGING, EASY TO USE, AND USEFUL TO SUPPORT E-CIGARETTE QUIT EFFORTS. AN OPEN LABEL PILOT IS TESTING THE USE OF THE APP WITH ENGAGEMENT METHODS COMMONLY USED IN DIGITAL INTERVENTIONS THAT WERE IDENTIFIED BY YOUTH AS IMPORTANT FOR ENGAGEMENT [TEXT MESSAGE REMINDERS & WEEKLY IN-PERSON CHECK-INS]; 8 HIGH SCHOOL ADOLESCENTS HAVE INITIATED THE TRIAL, ARE COMPLETING ALL APP SESSIONS, WEEKLY CHECK-INS, AND ASSESSMENTS WITH 100% RETENTION. THE CURRENT PROPOSAL WILL: AIM 1: EXAMINE THE EFFICACY OF THE KICK-NIC!© APP: WE WILL CONDUCT AN RCT WITH 306 ADOLESCENTS IN HIGH SCHOOLS WHO USE E-CIGARETTES REGULARLY (>/=1 DAY/WEEK IN THE PAST MONTH) AND WANT TO QUIT. ADOLESCENTS WILL BE RANDOMIZED TO THE ACTIVE (KICK-NIC!© APP FOR EIGHT WEEKS, ALONG WITH TEXT MESSAGE REMINDERS AND WEEKLY VIRTUAL CHECK-INS, & ASSESSMENTS) OR THE CONTROL CONDITION (ASSESSMENTS ALONE WITH REFERRALS TO NCI QUIT VAPING WEBPAGE). E-CIGARETTE USE WILL BE ASSESSED AT BASELINE, BIWEEKLY DURING TREATMENT, AND END OF TREATMENT (EOT; 8 WEEKS), AND THEN AT 1, 2, 3 AND 6 MONTH FOLLOW UPS (FU). SALIVARY COTININE LEVELS </= 30 NG/ML) WILL VERIFY SELF-REPORTS OF ABSTINENCE AT EOT AND 6-MONTH FU. WE WILL EXPLORE CHANGES IN OTHER TOBACCO AND CANNABIS USE BEHAVIORS. OUR PRIMARY OUTCOME WILL BE 7-DAY, BIOCHEMICALLY VERIFIED, POINT-PREVALENCE ABSTINENCE (PPA) RATES AT 6-MONTHS, AND SECONDARY OUTCOMES INCLUDE 7-DAY PPA AT EOT, % DAYS E-CIG FREE (DURING TREATMENT, AT EOT, 3 AND 6 MTHS FU) AND CONTINUOUS ABSTINENCE (AT EOT, 3 AND 6 MTHS FU). WE WILL ALSO EXAMINE THE IMPACT OF APP ENGAGEMENT, COPING SKILL KNOWLEDGE, AND BASELINE VARIABLES (NICOTINE DEPENDENCE, E-CIG USE FREQUENCY, SEX) AND OTHER TOBACCO PRODUCT USE ON OUTCOMES. AIM 2: IDENTIFY STRATEGIES FOR DISSEMINATION AND IMPLEMENTATION OF THE APP WITHIN SCHOOLS. INDIVIDUAL QUALITATIVE INTERVIEWS WITH UP TO 50% OF YOUTH IN THE ACTIVE CONDITION WILL EXAMINE LIKEABILITY OF THE APP AND ENGAGEMENT METHODS USED, HOW TO DISSEMINATE THE APP TO YOUTH IN SCHOOL SETTINGS. INTERVIEWS WITH 20 SCHOOL STAFF/ADMINISTRATORS WILL EXAMINE HOW THE APP COULD BE IMPLEMENTED AND USED WITHIN THE SCHOOL SETTING. THUS, THIS INNOVATIVE PROPOSAL WILL SUPPORT THE TESTING, AS WELL AS DISSEMINATION AND IMPLEMENTATION WITHIN SCHOOLS, OF AN APPEALING DIGITAL APP THAT ADDRESSES THE CRITICAL NEED FOR AN ADOLESCENT-FOCUSED E-CIGARETTE CESSATION INTERVENTION.

VAPING CESSATION AMONG YOUTH: EVALUATING THE FEASIBILITY AND EFFICACY OF A VIRTUAL IN-PERSON CBT AND AN APP-BASED CBT4CBT - PROJECT ABSTRACT E-CIGARETTES ARE THE MOST POPULAR NICOTINE-DELIVERY DEVICES USED BY US ADOLESCENTS. MANY ADOLESCENTS DO NOT LIKE BEING ADDICTED TO E-CIGARETTES AND WANT TO QUIT. HOWEVER, THERE ARE NO EMPIRICALLY VALIDATED INTERVENTIONS TO HELP THEM QUIT USING E-CIGARETTES. WE HAVE DEVELOPED AN ADOLESCENT-FOCUSED SMARTPHONE-APP CALLED KICK-NIC!© THAT USES AN ENGAGING, MULTI-MEDIA RICH, AND INTERACTIVE COGNITIVE-BEHAVIORAL THERAPY PLATFORM TO TEACH COPING SKILLS FOR E-CIGARETTE-SPECIFIC TRIGGERS AND SUPPORT CESSATION. APP CONTENT TO ADDRESS E-CIGARETTE APPEAL, QUIT MOTIVATIONS, AND COPING SKILLS, WAS DEVELOPED USING FOCUS GROUP EVIDENCE FROM 60 ADOLESCENT E-CIGARETTE USERS. THE STRUCTURE, FORMAT AND DESIGN OF THE APP WAS DEVELOPED USING ITERATIVE FEEDBACK FROM 14 ADOLESCENTS. A FEASIBILITY PILOT WITH 19 ADOLESCENTS WHO USED THE APP, INDICATED THAT IT WAS ENGAGING, EASY TO USE, AND USEFUL TO SUPPORT E-CIGARETTE QUIT EFFORTS. AN OPEN LABEL PILOT IS TESTING THE USE OF THE APP WITH ENGAGEMENT METHODS COMMONLY USED IN DIGITAL INTERVENTIONS THAT WERE IDENTIFIED BY YOUTH AS IMPORTANT FOR ENGAGEMENT [TEXT MESSAGE REMINDERS & WEEKLY IN-PERSON CHECK-INS]; 8 HIGH SCHOOL ADOLESCENTS HAVE INITIATED THE TRIAL, ARE COMPLETING ALL APP SESSIONS, WEEKLY CHECK-INS, AND ASSESSMENTS WITH 100% RETENTION. THE CURRENT PROPOSAL WILL: AIM 1: EXAMINE THE EFFICACY OF THE KICK-NIC!© APP: WE WILL CONDUCT AN RCT WITH 306 ADOLESCENTS IN HIGH SCHOOLS WHO USE E-CIGARETTES REGULARLY (>/=1 DAY/WEEK IN THE PAST MONTH) AND WANT TO QUIT. ADOLESCENTS WILL BE RANDOMIZED TO THE ACTIVE (KICK-NIC!© APP FOR EIGHT WEEKS, ALONG WITH TEXT MESSAGE REMINDERS AND WEEKLY VIRTUAL CHECK-INS, & ASSESSMENTS) OR THE CONTROL CONDITION (ASSESSMENTS ALONE WITH REFERRALS TO NCI QUIT VAPING WEBPAGE). E-CIGARETTE USE WILL BE ASSESSED AT BASELINE, BIWEEKLY DURING TREATMENT, AND END OF TREATMENT (EOT; 8 WEEKS), AND THEN AT 1, 2, 3 AND 6 MONTH FOLLOW UPS (FU). SALIVARY COTININE LEVELS </= 30 NG/ML) WILL VERIFY SELF-REPORTS OF ABSTINENCE AT EOT AND 6-MONTH FU. WE WILL EXPLORE CHANGES IN OTHER TOBACCO AND CANNABIS USE BEHAVIORS. OUR PRIMARY OUTCOME WILL BE 7-DAY, BIOCHEMICALLY VERIFIED, POINT-PREVALENCE ABSTINENCE (PPA) RATES AT 6-MONTHS, AND SECONDARY OUTCOMES INCLUDE 7-DAY PPA AT EOT, % DAYS E-CIG FREE (DURING TREATMENT, AT EOT, 3 AND 6 MTHS FU) AND CONTINUOUS ABSTINENCE (AT EOT, 3 AND 6 MTHS FU). WE WILL ALSO EXAMINE THE IMPACT OF APP ENGAGEMENT, COPING SKILL KNOWLEDGE, AND BASELINE VARIABLES (NICOTINE DEPENDENCE, E-CIG USE FREQUENCY, SEX) AND OTHER TOBACCO PRODUCT USE ON OUTCOMES. AIM 2: IDENTIFY STRATEGIES FOR DISSEMINATION AND IMPLEMENTATION OF THE APP WITHIN SCHOOLS. INDIVIDUAL QUALITATIVE INTERVIEWS WITH UP TO 50% OF YOUTH IN THE ACTIVE CONDITION WILL EXAMINE LIKEABILITY OF THE APP AND ENGAGEMENT METHODS USED, HOW TO DISSEMINATE THE APP TO YOUTH IN SCHOOL SETTINGS. INTERVIEWS WITH 20 SCHOOL STAFF/ADMINISTRATORS WILL EXAMINE HOW THE APP COULD BE IMPLEMENTED AND USED WITHIN THE SCHOOL SETTING. THUS, THIS INNOVATIVE PROPOSAL WILL SUPPORT THE TESTING, AS WELL AS DISSEMINATION AND IMPLEMENTATION WITHIN SCHOOLS, OF AN APPEALING DIGITAL APP THAT ADDRESSES THE CRITICAL NEED FOR AN ADOLESCENT-FOCUSED E-CIGARETTE CESSATION INTERVENTION.